Prolotherapy is a complementary treatment for muscle and joint pain. It is an injection of any substance that promotes growth of normal cells and tissues. These Injections cause activation of the inflammatory cascade to produce growth factors. These solutions often include dextrose for a growth factor stimulation effect, but the inflammatory signals that result causes a more vigorous growth response. The treatment involves repeated injections of an irritant solution into part of a joint or a supporting tendon or ligament.
Since the primary pathology in chronic sprain/strain is best described as connective tissue insufficiency, connective tissue laxity and/or weakness, Prolotherapy injections can help repair and diminish pain from chronic musculoskeletal conditions.